Reconstructed Central Carbohydrate Metabolism (CCM) of Sulfolobus solfataricus

Zaparty et al. 2009, [PubMed]

Pathway Maps and Enzymes

CCM pathway map. Identified CCM reactions (enzyme abbreviations boxed) involved in the branched ED and the EMP pathway (reactions numbered 1-13), the citric acid cycle including the glyoxylate shunt (dotted arrows) the reversed ribulose monophosphate pathway, C3/C4 conversions (dashed arrows) as well as glycogen and trehalose metabolism.

Abbreviations: Intermediates: DHAP, dihydroxy acetonephosphate; Ery4P, erythrose 4-phosphate; F6P, fructose 6-phosphate; fructose 1,6P2, fructose 1,6-bisphosphate; GAP, glyceraldehyde 3-phosphate; G6P, glucose 6-phosphate; KD(P)G, 2-Keto-3-deoxy-6-(phospho)gluconate; KD(P)Gal, 2-Keto-3-deoxy-6-(phospho)galactonate.

Enzymes (including EC number): ACN, aconitase (EC 4.2.1.3); CS, citrate synthase (EC 2.3.3.1); ENO, enolase (6; EC 4.2.1.11); FBPA, fructose-1,6-bisphosphate aldolase (EC 4.1.2.13); FBPase, fructose-1,6-bisphosphatase (EC 3.1.3.11); FumR, fumarate hydratase (EC 4.2.1.2); GA, glucan-1,4-α-glucosidase (EC 3.2.1.3); GAD, gluconate dehydratase (2; EC 4.2.1.39); GADH, glyceraldehyde dehydrogenase (4; EC 1.2.1.3); GAPDH, glyceraldehyde-3-phosphate dehydrogenase (9; EC 1.2.1.12/13); GAPN, non-phosphorylating GAP dehydrogenase (11; EC 1.2.1.9 ); GDH, glucose dehydrogenase (1A; EC 1.1.47); GK, glycerate kinase (5; EC 2.7.1-); GL, gluconolactonase (1B; EC 3.1.17); GLGA, glycogen synthase (EC 2.4.1.11); GLGP, glycogen phosphorylase (EC 2.4.1.1); ICL, isocitrate lyase (EC 4.1.3.1); IDH, isocitrate dehydrogenase (EC 1.1.1.41); KD(P)GA, KD(P)G aldolase (3; active on KDG as well as KDPG; EC 4.1.2.-); KDGK, KDG kinase (8; EC 2.7.1.45); MAE, malic enzyme (EC 1.1.1.38); MDH, malate dehydrogenase (EC 1.1.1.37); MS, malate synthase (EC 2.3.3.9); OOR, α-oxoglutarate ferredoxin oxidoreductase (EC 1.2.7.3); PEPC, PEP carboxylase (EC 4.1.1.31); PEPCK, PEP carboxykinase (EC 4.1.1.32); PEPS, phosphoenolpyruvate synthetase (13; EC 2.7.9.2); PGAM, phosphoglycerate mutase (12; EC 5.4.2.1); PGI, glucose-6-phosphate isomerase (EC 5.3.1.9); PGK, phosphoglycerate kinase (10; EC 2.7.2.3); PGM, phosphoglucomutase (EC 5.4.2.2); PHI/HPS 3-hexulose-6-phosphate isomerase / 3-hexulose-6-phosphate synthase (EC 5.-.-.-/4.1.2.-); PK, pyruvate kinase (7; EC 2.7.1.40); POR, pyruvate synthase (EC 1.2.7.1); PRS, ribose phosphate pyrophosphokinase (EC 2.7.6.1); PYC, pyruvate carboxylase (EC 6.4.1.1); RBSK, ribokinase (EC 2.7.1.15); RPI, ribose-5-phosphate isomerase (EC 5.3.1.6); SDH, succinate dehydrogenase (EC1.3.99.1); Succ-CoA Syn, succinyl-cenzymA synthetase (EC 6.2.1.5); TIM, triosephosphate isomerase (EC 5.3.1.1); TK, transketolase (EC 2.2.1.1); TreT, trehalose glycosyltransferring synthase (2.4.1.B2); TreY, maltooligosyltrehalose synthase (EC 5.4.99.15); TreZ, trehalose hydrolase (EC 3.2.1.141).