Reconstructed Central Carbohydrate Metabolism (CCM) of Sulfolobus solfataricus

Zaparty et al. 2009, [PubMed]

Pathway Maps and Enzymes

CCM pathway map. Identified CCM reactions (enzyme abbreviations boxed) involved in the branched ED and the EMP pathway (reactions numbered 1-13), the citric acid cycle including the glyoxylate shunt (dotted arrows) the reversed ribulose monophosphate pathway, C3/C4 conversions (dashed arrows) as well as glycogen and trehalose metabolism.

Abbreviations: Intermediates: DHAP, dihydroxy acetonephosphate; Ery4P, erythrose 4-phosphate; F6P, fructose 6-phosphate; fructose 1,6P2, fructose 1,6-bisphosphate; GAP, glyceraldehyde 3-phosphate; G6P, glucose 6-phosphate; KD(P)G, 2-Keto-3-deoxy-6-(phospho)gluconate; KD(P)Gal, 2-Keto-3-deoxy-6-(phospho)galactonate.

Enzymes (including EC number): ACN, aconitase (EC; CS, citrate synthase (EC; ENO, enolase (6; EC; FBPA, fructose-1,6-bisphosphate aldolase (EC; FBPase, fructose-1,6-bisphosphatase (EC; FumR, fumarate hydratase (EC; GA, glucan-1,4-α-glucosidase (EC; GAD, gluconate dehydratase (2; EC; GADH, glyceraldehyde dehydrogenase (4; EC; GAPDH, glyceraldehyde-3-phosphate dehydrogenase (9; EC; GAPN, non-phosphorylating GAP dehydrogenase (11; EC ); GDH, glucose dehydrogenase (1A; EC 1.1.47); GK, glycerate kinase (5; EC 2.7.1-); GL, gluconolactonase (1B; EC 3.1.17); GLGA, glycogen synthase (EC; GLGP, glycogen phosphorylase (EC; ICL, isocitrate lyase (EC; IDH, isocitrate dehydrogenase (EC; KD(P)GA, KD(P)G aldolase (3; active on KDG as well as KDPG; EC 4.1.2.-); KDGK, KDG kinase (8; EC; MAE, malic enzyme (EC; MDH, malate dehydrogenase (EC; MS, malate synthase (EC; OOR, α-oxoglutarate ferredoxin oxidoreductase (EC; PEPC, PEP carboxylase (EC; PEPCK, PEP carboxykinase (EC; PEPS, phosphoenolpyruvate synthetase (13; EC; PGAM, phosphoglycerate mutase (12; EC; PGI, glucose-6-phosphate isomerase (EC; PGK, phosphoglycerate kinase (10; EC; PGM, phosphoglucomutase (EC; PHI/HPS 3-hexulose-6-phosphate isomerase / 3-hexulose-6-phosphate synthase (EC 5.-.-.-/4.1.2.-); PK, pyruvate kinase (7; EC; POR, pyruvate synthase (EC; PRS, ribose phosphate pyrophosphokinase (EC; PYC, pyruvate carboxylase (EC; RBSK, ribokinase (EC; RPI, ribose-5-phosphate isomerase (EC; SDH, succinate dehydrogenase (EC1.3.99.1); Succ-CoA Syn, succinyl-cenzymA synthetase (EC; TIM, triosephosphate isomerase (EC; TK, transketolase (EC; TreT, trehalose glycosyltransferring synthase (2.4.1.B2); TreY, maltooligosyltrehalose synthase (EC; TreZ, trehalose hydrolase (EC